DHT Inhibitors and Its Effect on Hair Loss

The most commonly implicated androgen in hair loss is dihydrotestosterone (DHT), which is a very potent form of testosterone. It is created in the body by the conversion of testosterone. There is an enzyme (enzymes are just proteins that speed up biochemical reactions) known as 5-alpha reductase. It has this name because it “reduces”, or adds hydrogedhtn, at the 5 position of the steroid molecule. 
Well, it stands to reason that if we could decrease the amount of this enzyme, 5-alpha reductase, in the blood or in the hair follicles, then less testosterone would be converted to DHT, and therefore DHT levels would be lower. This is exactly the mechanism behind the drug Propecia (finasteride); it is a 5-alpha reductase inhibitor and thus decreases blood levels of DHT.
However, this sometimes causes problems, such as erectile dysfunction, diminished sex drive, and, rarely, enlargement of breast tissue in males (a distressing condition known as gynecomastia). It may be advantageous to use topical (applied to the hair and scalp) 5-alpha reductase inhibitors in order to avoid or minimize such side effects. This is one of the ways that the Hair Cycle products were designed, that is, they contain topical 5-alpha reductase inhibitors as well as androgen receptor blockers. 
The androgen receptor is a protein structure that sits in the cell membrane. When an androgen, such as DHT, occupies, or fits into, this receptor site, it causes an effect on the interior of the cell. This is a common mechanism of all hormones; there are receptors for all hormones on various cell membranes, and this is the major way that they exert their physiological effects. Receptor blocking agents are designed to fit into the receptor site, but to NOT have any effect. Therefore, they have a blocking effect. An androgen receptor blocking agent will, for instance, occupy the androgen receptor on the hair follicle cell membranes. This prevents some of the DHT that is in the area from attaching to the membrane and having its effect (that is, promoting hair loss).

So we see a two-fold effect from the Hair Cycle products in terms of DHT: one, they decrease the conversion of testosterone to DHT, leading to lower levels, and two, the DHT that IS left finds it difficult to find unoccupied receptors to which it can attach and have an effect. This is beneficial in people with hair loss.

Related items

  • About Haircycle

    What is Hair Cycle? Hair Cycle is a product line which is physician formulated to provide the highest degree of purity in its natural ingredients. The products clean and condition the hai ...
  • Physicians Area

    Faster Healing, Fewer “Lost Grafts” from Unique Scientific Formulation A new product from HairCycle promotes dramatic healing in new grafts. HairCycle products are physician formulate ...
  • Hair Loss Products

    The History of Hair Loss In all cultures hair and all throughout history, hair had a special significants and played an important roll for power, youth, beauty and attraction in ancient a ...
Home DHT Inhibitors

Connect with us

Latest Blogs

Prev Next

Hair Cycle Shampoo advantages

Hair Cycle Shampoo advantages

Dear Dr. Cole, What are the advantages to using Hair Cycle Shampoo? Hair Cycle Shampoo contains no harsh chemicals that strip your hair of its natural shine.  When used in conjunction with the specially formulated Hair Cycle Conditioner, the line buffers the lubricating fatty acid layer on the outer sheath of...

Biotin Spray with Saline Spray?

Hello. i am receiving a hair transplant in 2 days and wanted to know when do i use the biotin spray? Is it immediately after im finished or do i use the saline spray my doctor gives me first? biotin can be used during the surgery and immediately after the procedure....

Hair loss and Ferritin Level

  I am 20 years old and have semi curly hair. The hair were not very dense but still they were quite heavy. I have a low level of hb and I got my s. ferritin checked which was also very low. I have excessive hair loss, specially in front and...

Live support

Available Monday - Friday, 9 AM - 5 PM EST

Our brand's address

1

1070 Powers Place, Alpharetta, Georgia, 30009, United States

Toll Free: 1-800-942-7482, Tel: (240) 393-2000, Mail: webmaster@haircycle.com